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American Journal of Industrial Medicine - vol. 58 n° S1 -

"Introduction
At the time of the 1930 International Labour Office Conference on silicosis in Johannesburg, mining was the main sector affected by silicosis; however, other industries would later emerge as areas of concern.
Methods
A search of the occupational hygiene and epidemiological literature was conducted to retrieve historical and current documents pertaining to silica exposure and associated hazards.
Results
The potential risk of silicosis in construction became evident starting in the 1960s, and the body of literature including case reports, sampling surveys, and medical surveillance continues to grow to this day. Among non-construction activities, hydraulic fracturing and engineered countertop manufacturing have recently appeared as industries with a potential for overexposure, while mining remains the industrial sector with the highest prevalence of exposure.
Conclusions
The risk of developing this “ancient disease” remains a current issue in many workplaces, and requires ongoing surveillance and prevention efforts."
"Introduction
At the time of the 1930 International Labour Office Conference on silicosis in Johannesburg, mining was the main sector affected by silicosis; however, other industries would later emerge as areas of concern.
Methods
A search of the occupational hygiene and epidemiological literature was conducted to retrieve historical and current documents pertaining to silica exposure and associated hazards.
Results
The potential risk of ...

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HesaMag - n° 27 -

"The Tripode building in Nantes, France, which housed government offices, was destroyed in 2005. It contained 350 tonnes of asbestos. Trade union delegate Francis Judas, who was instrumental in the fight to secure recognition of the occupational illnesses of employees caused by exposure to asbestos in the building, tells HesaMag the story of the Tripode and explains why exposure throughout the working day to 10,000 fibres per cubic metre is equivalent to a death threat for workers."
"The Tripode building in Nantes, France, which housed government offices, was destroyed in 2005. It contained 350 tonnes of asbestos. Trade union delegate Francis Judas, who was instrumental in the fight to secure recognition of the occupational illnesses of employees caused by exposure to asbestos in the building, tells HesaMag the story of the Tripode and explains why exposure throughout the working day to 10,000 fibres per cubic metre is ...

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HesaMag - n° 27 -

"L'immeuble Tripode, qui abritait des bureaux ministériels à Nantes en France, a été détruit en 2005. Il contenait 350 tonnes d'amiante. Francis Judas, syndicaliste, qui a joué un rôle déterminant dans la lutte pour la reconnaissance des maladies professionnelles des salariés dues à l'exposition à l'amiante dans le bâtiment, nous raconte l'histoire de cette lutte et explique pourquoi une exposition tout au long de la journée de travail à 10000 fibres par mètre cube équivaut à une menace de mort pour les travailleurs."
"L'immeuble Tripode, qui abritait des bureaux ministériels à Nantes en France, a été détruit en 2005. Il contenait 350 tonnes d'amiante. Francis Judas, syndicaliste, qui a joué un rôle déterminant dans la lutte pour la reconnaissance des maladies professionnelles des salariés dues à l'exposition à l'amiante dans le bâtiment, nous raconte l'histoire de cette lutte et explique pourquoi une exposition tout au long de la journée de travail à 10000 ...

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08.12.9-68735

"Entre 1972 et 1993, 1800 agents de l'Insee, du Trésor Public et du ministère des Affaires étrangères ont été exposés intensément aux flocages d'amiante dans la tour Tripode Beaulieu de Nantes. Très rapidement, à l'instar des voix dénonçants la dangerosité de cette fibre, travailleurs et syndicalistes du Tripode se mobilisent et font pression sur leur employeur : l'Etat, à la fois législateur et patron. Le bâtiment est finalement évacué en 1992-1993 et rasé en 2005 après de longs travaux de désamiantage. Restent les malades et ceux craignant de l'être un jour...
Sous la forme d'une histoire dessinée, ce livre raconte le combat mené dans l'unité syndicale depuis près de quarante ans pour briser le mur de silence entourant l'utilisation de cette "poussière du diable""
"Entre 1972 et 1993, 1800 agents de l'Insee, du Trésor Public et du ministère des Affaires étrangères ont été exposés intensément aux flocages d'amiante dans la tour Tripode Beaulieu de Nantes. Très rapidement, à l'instar des voix dénonçants la dangerosité de cette fibre, travailleurs et syndicalistes du Tripode se mobilisent et font pression sur leur employeur : l'Etat, à la fois législateur et patron. Le bâtiment est finalement évacué en ...

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Cancers - vol. 13 n° 9 -

"Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors."
"Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is ...

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International Journal of Environmental Research and Public Health - vol. 19 n° 9 -

"The International Agency for Research on Cancer established a causal link between asbestos exposure and ovarian cancer. However, the exposure frequency and histological characteristics of asbestos-associated ovarian cancers remain to be investigated in detail. This multicenter case–case study assessed the asbestos exposure in ovarian carcinoma (OC) patients, alongside its association with histological subtype. Women were recruited in four hospitals in Lyon, France. Histological reports were reviewed by a pathologist. Patient and family members' data were collected by phone-based questionnaires. Asbestos exposure was defined as direct (occupational and environmental) and indirect (via parents, partners, and children). An industrial hygienist assessed the probability and level of exposure. The 254 enrolled patients (mean age 60 years) reported having an average of 2.3 different jobs (mean working duration 29 years). The prevalence of direct and indirect asbestos exposure was 13% (mean exposure duration 11 years) and 46%, respectively. High-grade serous carcinoma accounted for 73% of all OCs and 82% of histological subtypes in women with direct exposure. After adjustment on a familial history of OC, no significant associations between asbestos exposure (direct and/or indirect) and high-grade serous carcinoma were found. Women with OC had a high prevalence of asbestos exposure. Establishing risk profiles, as reported here, is important in facilitating compensation for asbestos-related OCs and for the surveillance of women at risk."
"The International Agency for Research on Cancer established a causal link between asbestos exposure and ovarian cancer. However, the exposure frequency and histological characteristics of asbestos-associated ovarian cancers remain to be investigated in detail. This multicenter case–case study assessed the asbestos exposure in ovarian carcinoma (OC) patients, alongside its association with histological subtype. Women were recruited in four ...

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Occupational Medicine - vol. 73 n° 9 -

"Background:
The association between asbestos exposure and ovarian cancer has been questioned given the possible misdiagnosis of peritoneal mesothelioma as ovarian cancer.
Aims:
To update a systematic review on ovarian cancer risk in women occupationally exposed to asbestos, exploring the association with the time since first exposure and the duration of exposure.
Methods:
We searched PubMed from 2008 onwards, screened previous systematic reviews, combined standardized mortality ratios (SMR) using random effect models and quantified heterogeneity using the I2 statistic. To assess tumour misclassification, we compared the distribution of observed excess ovarian cancers (OEOC) to that expected (EEOC) from the distribution of peritoneal cancers in strata of latency and exposure duration.
Results:
Eighteen publications (20 populations), including a pooled analysis of 21 cohorts, were included. The pooled SMR was 1.79 (95% confidence interval 1.38-2.31), with moderate heterogeneity between studies (I2 = 42%), based on 144 ovarian cancer deaths/cases. The risk was increased for women with indirect indicators of higher exposure, longer duration and latency, and lower for chrysotile than for crocidolite exposure. The effect of duration and latency could not be completely disentangled, since no multivariate analysis was available for time-related variables. The dissimilarity index between OEOC and EEOC for the time since first exposure was small suggesting a similar pattern of risk.
Conclusions:
While some misclassification between ovarian and peritoneal cancers cannot be excluded, the observed excess risk of ovarian cancer should be added to the overall disease burden of asbestos."
"Background:
The association between asbestos exposure and ovarian cancer has been questioned given the possible misdiagnosis of peritoneal mesothelioma as ovarian cancer.
Aims:
To update a systematic review on ovarian cancer risk in women occupationally exposed to asbestos, exploring the association with the time since first exposure and the duration of exposure.
Methods:
We searched PubMed from 2008 onwards, screened previous systematic ...

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Environmental Health - vol. 18 n° 27 -

"Background
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on the association between occupational leather dust exposure and the risk of oral, pharyngeal, and laryngeal cancers. The objective of this study was to investigate the association between the risk of HNC and occupational exposure to leather dust.
Methods
Lifestyle habits and occupational history were collected for 2161 patients with squamous cell carcinoma of oral cavity, pharynx, and larynx, and 3555 controls, using a standardized questionnaire. Occupational exposure to leather dust was assessed using a job-exposure matrix. Odds ratios (OR) and 95% confidence intervals (CI) for HNC globally and by subsite were estimated using multivariate unconditional, and polytomous logistic regressions, respectively.
Results
Cumulative lifetime exposure to leather dust < 6 mg/m3-years was associated with an increased risk of laryngeal cancer (OR = 2.26, 95% CI: 1.07–4.76); higher levels were not related to elevated risks of HNC. Some tasks performed and the use of some glues were associated with elevated, although non-significant, risks of HNC. No dose-response relationships were observed.
Conclusion
Our study did not provide enough evidence for an increased risk of HNC related to occupational exposure to leather dust. Further studies are needed to understand the risks of specific tasks in the leather industry."
"Background
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on the association between occupational leather dust exposure and the risk of oral, pharyngeal, and laryngeal cancers. The objective of this study was to investigate the association between the risk of HNC and occupational exposure ...

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Occupational and Environmental Medicine - n° Early View -

"Objectives:
There is sufficient evidence for a causal association of sinonasal epithelial cancers (SNEC) only for exposure to wood and leather dusts, nickel compounds and employment in isopropyl alcohol production. The aim of this study was to assess whether other occupational hazards are associated with the risk of SNEC for the main histologic types, namely adenocarcinoma (AD) and squamous cell carcinoma (SCC).
Methods:
The study population included 375 incident SNEC cases collected from 1996 to 2014 (79% of all diagnosed SNEC) throughout the Piedmont region by the regional Sinonasal Cancer Registry, and 408 hospital controls. Exposure to 17 occupational agents was assigned through expert assessment based on interviews to the subjects on jobs held throughout their working life. The relationship of SNEC with ever and cumulative exposure to the hazards was assessed through unconditional logistic regression models adjusted for age, sex, area of residence, smoking habit, year of enrolment and coexposures.
Results:
AD was associated with both ever and cumulative exposure to wood dust, leather dust and organic solvents, and with cumulative exposure to textiles dusts. SCC risk was significantly increased by ever exposure to nickel, chromium and welding fumes, as well as by cumulative exposure to welding fumes, arsenic and organic solvents. A mixed group of other histological types was associated with both ever and cumulative exposure to wood dust and textile dusts.
Conclusions:
The associations of SNEC with wood dust, leather dust and nickel were confirmed, while some new associations were observed for other hazards, which merit further investigation."
"Objectives:
There is sufficient evidence for a causal association of sinonasal epithelial cancers (SNEC) only for exposure to wood and leather dusts, nickel compounds and employment in isopropyl alcohol production. The aim of this study was to assess whether other occupational hazards are associated with the risk of SNEC for the main histologic types, namely adenocarcinoma (AD) and squamous cell carcinoma (SCC).
Methods:
The study population ...

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European Journal of Health Economics - vol. 15

"Purpose
The objective of this article was to estimate the social cost of respiratory cancer cases attributable to occupational risk factors in France in 2010.
Methods
According to the attributable fraction method and based on available epidemiological data from the literature, we estimated the number of respiratory cancer cases due to each identified risk factor. We used the cost-of-illness method with a prevalence-based approach. We took into account the direct and indirect costs. We estimated the cost of production losses due to morbidity (absenteeism and presenteeism) and mortality costs (years of production losses) in the market and nonmarket spheres.
Results
The social cost of lung, larynx, sinonasal and mesothelioma cancer caused by exposure to asbestos, chromium, diesel engine exhaust, paint, crystalline silica, wood and leather dust in France in 2010 were estimated at between 917 and 2,181 million euros. Between 795 and 2,011 million euros (87–92 %) of total costs were due to lung cancer alone. Asbestos was by far the risk factor representing the greatest cost to French society in 2010 at between 531 and 1,538 million euros (58–71 %), ahead of diesel engine exhaust, representing an estimated social cost of between 233 and 336 million euros, and crystalline silica (119–229 million euros). Indirect costs represented about 66 % of total costs.
Conclusion
Our assessment shows the magnitude of the economic impact of occupational respiratory cancers. It allows comparisons between countries and provides valuable information for policy-makers responsible for defining public health priorities."
"Purpose
The objective of this article was to estimate the social cost of respiratory cancer cases attributable to occupational risk factors in France in 2010.
Methods
According to the attributable fraction method and based on available epidemiological data from the literature, we estimated the number of respiratory cancer cases due to each identified risk factor. We used the cost-of-illness method with a prevalence-based approach. We took into ...

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