Documents Schachter, Neil E. 2 results

A study of respiratory function and immunological status of 17 female workers employed in a small latex (9006046) glove manufacturing facility in Zagreb, Croatia was reported. The workers prepared latex solution from the original rubber material collected from rubber trees. Thirteen participants were nonsmokers and four were light smokers. The controls were 17 females employed as food packagers in a confectionery factory who were not exposed to latex and were matched to the cohort by age and smoking status. The subjects completed a respiratory symptom questionnaire. Spirometric testing was performed. Skin prick testing was performed using aqueous extracts of latex and latex gloves and common aeroallergens. Industrial hygiene monitoring for dusts was performed. The latex glove workers reported a significantly higher prevalence of chronic respiratory symptoms such as dyspnea, chronic cough and hoarseness than the controls. One of the latex workers, a nonsmoker, had symptoms of occupational asthma. A high prevalence of overshift (acute) symptoms such as eye irritation, nasal dryness, throat irritation, cough, dyspnea, and headache was also reported by the latex workers. Forced vital capacity (FVC), one second forced expiratory volume, and flow rates at 50 and 75% of FVC (FEF75) were significantly lower in the latex workers than in the controls. The most pronounced decrease was seen in FEF75. Only one latex worker reacted to skin testing with the latex extracts. She also reported symptoms compatible with occupational asthma. None of the subjects reacted to the common aeroallergens. Talc (14807966) was the major dust to which the latex workers were exposed. The total and respirable talc dust concentrations averaged 7.7 and 1.9mg/m3, which exceeded the Croatian standards of 1.5 and 0.5mg/m3, respectively. The authors conclude that, besides occupational asthma, exposures associated with latex glove manufacturing are associated with frequent nonspecific respiratory symptoms.

A survey of respiratory health in Croatian synthetic fiber textile workers was conducted. The cohort consisted of 400 workers, 308 females, 18 to 61 years old, employed in a synthetic textiles factory at Zagreb, Croatia. The workers had been employed at the facility a mean of 16 years. Forty one percent of the female workers and 45% of males were current smokers. Controls consisted of 806 workers in other industries not exposed to dusts, fumes, or chemicals who were matched to the cohort by age, duration of employment, and smoking habits. Subjects completed a respiratory symptom questionnaire. Spirometric testing was performed. Industrial hygiene monitoring for total and respirable dust at the textile factory was performed. Textile workers reported a higher prevalence of chronic respiratory symptoms than controls. The differences were statistically significant for dyspnea, sinusitis, and nasal catarrh in female workers and nasal catarrh in the male workers. Significant higher prevalences of chronic cough, bronchitis, and phlegm production were reported by smoking than by nonsmoking textile workers. Three female textile workers and one male worker had occupational asthma. None of the controls had asthma. The textile workers reported high prevalences of acute symptoms such as cough, nose and throat dryness, and eye irritation. A high prevalence of workshift related headache was reported by female textile workers. The prevalence of acute symptoms did not depend on smoking status. Forced vital capacity (FVC) and maximum expiratory flow rate at the last 25% of FVC (FEF75) were decreased in the textile workers compared to the controls. The decreases were statistically significant only for FEF75 in female smokers and nonsmokers and FEF75 in male nonsmokers. The mean total and respirable dust concentrations in the textile factory were 12 and 4mg/m3, which exceeded the Croatian standards of 1 and 0.4mg/m3, respectively. The authors conclude that work in synthetic textile factories may cause respiratory impairment.