Disruption of sex hormones and oxidative homeostasis in parturient women and their matching fetuses at an e-waste recycling site in China
Zhou, Xue ; Ju, Ying ; Wu, Zhigang ; Yang, Kedi
International Journal of Occupational and Environmental Health
2013
19
1
22-28
biological monitoring ; electronic equipment ; endocrine disrupters ; exposure assessment ; pregnant women ; recycling of materials ; reproductive hazards
Occupational risks
http://dx.doi.org/10.1179/2049396712Y.0000000017
English
Bibliogr.
"Background: Electronic waste (e-waste) disposal poses a major health concern in developing countries.Objectives: We investigated whether prenatal exposure to e-waste pollutants affects sex hormones and oxidative status.Methods: Parturient women living in an e-waste recycling site (exposed subjects, n = 46) and a reference site (referents, n = 44) were recruited.Results: Compared with referents, the levels of sex hormones estradiol and progesterone were significantly elevated in exposed subjects (P<0·05); a significant increase in the mRNA levels of estrogen receptor alpha and beta, and a significant decrease in the mRNA levels of progesterone receptor were detected in exposed subjects (P<0·05); a significant increase in malondialdehyde, and suppression of the activities of superoxide dismutase and glutathione peroxidase (P<0·05) were observed in exposed subjects.Conclusions: Our results revealed that sex hormones and oxidative homeostasis were disrupted in pregnant women and their fetuses at the e-waste recycling site."
Paper
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