"This paper is about industrial chemicals, the manner in which their toxicity is assessed and the use of such assessments in regulatory decision-making. It begins with general points concerning toxicological data availability and hazard identification, then moves on to risk assessment and occupational exposure limits, and finally looks briefly at three specific toxicological issues, asthma, chronic toxic encephalopathy, and ‘‘low toxicity'' dust effects on the lung, where the science is far from resolved. The overall purpose of the paper is to raise, or perhaps to act as a reminder of a number of issues of particular relevance to industrial chemicals and the occupational setting, and hopefully to prompt further thinking and perhaps some new initiatives directed at the areas in question (as REACH, the new European regulatory system)."

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