"A detailed evaluation of the principles and methods currently used to explore the association between exposure to chemicals and the development of adverse neurobehavioural changes. Emphasis is placed on the use of animals as systems to model and predict adverse reactions in the human nervous system.
The book has five sections. The first deals with general factors to be considered in the design of neurotoxicity studies and in the statistical analysis of their results. Experience acquired in the recent outbreaks of poisoning from methyl mercury and carbon disulfide are used to demonstrate both the importance of evaluating the neurotoxicity of chemicals and the power of animal studies to predict human responses. The remaining sections provide extensive information on methods developed in each of the four major research disciplines that contribute to the neurotoxic assessment of environmental chemicals. "

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