Documents hormone secretion 5 results

"This study examined the effects of psychosocial job strain on the excretion of neuroendocrine stress hormones (adrenaline, noradrenaline, and cortisol) on workdays and days off. ... Psychosocial job strain is associated with greater noradrenaline excretion over time. This finding suggests unwinding sympathetic nervous activity. The low cortisol levels of the high-strain group may indicate circadian rhythm disturbance induced by job strain. Supervisory relationships may have a particular influence for the studied occupation because the participants had more administrative contact with supervisors than support at the worksite; therefore, supervisory support may increase adrenaline excretion."

"Perfluorooctanoic acid (PFOA), a potent synthetic surfactant used in industrial applications, is a peroxisome proliferator that has resulted in dose-related increases in hepatic, pancreatic acinar, and Leydig cell adenomas in laboratory animals. In addition, PFOA increased serum estradiol levels through the induction of hepatic aromatase activity. In 1993 and 1995, we conducted two cross-sectional studies of 111 and 80 production workers, respectively, and specifically measured their serum PFOA in relation to several reproductive hormones to determine whether such an effect occurs in humans. PFOA was not significantly associated with estradiol or testosterone in either year's study. A 10% increase in mean estradiol levels was observed among employees who had the highest levels of serum PFOA, although this association was confounded by body mass index. Neither was PFOA consistently associated with the other measured hormones. Our results provide reasonable assurance that, in this production setting, there were no significant hormonal changes associated with PFOA at the serum levels measured. Limitations of this investigation include its cross-sectional design, the few subjects exposed at the highest levels, and the lower levels of serum PFOA measured, compared with those levels reported to cause effects in laboratory animal studies."

"In a study of pesticide factory workers exposed to organophosphate pesticides, there was a negative correlation between urinary levels of follicle-stimulating hormone (FSH) and sperm count and between urinary FSH level and sperm concentration. Pesticide exposure alone was associated with serum level of luteinizing hormone (LH) but not with serum FSH or testosterone or with any urinary hormone levels. With adjustment for age, rotating shift work, cigarette smoking and alcohol consumption, exposure increased serum LH level; serum FSH level was slightly elevated and the serum testosterone level was decreased with increasing exposure. Age and rotating shift work appeared to act as confounders. It was concluded that organophosphate pesticides have a small effect on male reproductive hormones, suggestive of a secondary hormonal disturbance after testicular damage. "

"The possibility that shift working can increase the potential for women to contract breast cancer needs further study according to a new research report published by the Health and Safety Executive (HSE). In his work for HSE, Professor Swerdlow considered the results of four published epidemiological studies which addressed the possible relationship between breast cancer risk and shift work, and considered other relevant scientific information.
A potential mechanism for a relation between shift work and breast cancer risk would be via an effect of altered light exposure at night on levels of melatonin or other hormones that might affect cancer risk …"